Abstract
Background To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Methods Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Correlations between serum MIAT and serum IL-6 and TNF-α were analyzed. Risk factors for patients with CAD were analyzed by multiple factor analysis. Results Compared with healthy donors, serum lncRNA-MIAT was significantly increased in CAD patients. Serum MIAT was positively correlated with serum IL-6 and TNF-α in CAD. Multivariate analysis found that hypertension (OR (95% CI) = 3.471 (2.180–4.091), P=0.011), diabetes (OR (95% CI) = 3.682 (1.698–4.897), P=0.003), HDL-C (OR (95% CI) = 3.372 (1.760–6.920), P=0.001), and serum MIAT expression (OR (95% CI) = 2.687 (1.683–7.468), P=0.001) were independent risk factors for CAD. Conclusions Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD.
Highlights
Atherosclerosis is a chronic systemic inflammatory response that occurs under the interaction of various factors such as abnormal lipid metabolism, chronic inflammation, immune disorders, and genetics of the pathological basis of many cardiovascular diseases [1]
Comparison of Clinical Pathological Features between coronary atherosclerotic heart disease (CAD) Patients and Healthy Subjects. e data of clinical and pathological features in 102 patients with CAD and 89 healthy controls were compared, and the results are shown in Table 1. ere was no significant difference in age, sex, smoking history, glycosylated hemoglobin A1c (HbA1c), triglyceride (TG), total cholesterol (TC), lowdensity lipoprotein-cholesterol (LDL-C), high-sensitivity C-reactive protein, and lipoprotein a (Lp) between the two groups (P > 0.05)
There was significant difference in hypertension history, diabetes history, and high-density lipoprotein-cholesterol (HDLC) (P < 0.05). e number of patients with hypertension and diabetes in the CAD group was more than healthy controls (P < 0.05). e level of HDL-C in the CAD group was significantly lower than that in healthy subjects (P < 0.05)
Summary
Atherosclerosis is a chronic systemic inflammatory response that occurs under the interaction of various factors such as abnormal lipid metabolism, chronic inflammation, immune disorders, and genetics of the pathological basis of many cardiovascular diseases [1]. Numerous studies suggest that lncRNAs are involved in and play an important role in tumorigenesis and progression [7]. To study the expression and clinical significance of long noncoding RNA- (lncRNA-) MIAT in patients with coronary atherosclerotic heart disease (CAD). Serum MIAT, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) in 106 CAD patients and 89 healthy donors were detected. Serum lncRNA-MIAT was significantly increased in CAD patients. Multivariate analysis found that hypertension (OR (95% CI) 3.471 (2.180–4.091), P 0.011), diabetes (OR (95% CI) 3.682 (1.698–4.897), P 0.003), HDL-C (OR (95% CI) 3.372 (1.760–6.920), P 0.001), and serum MIAT expression (OR (95% CI) 2.687 (1.683–7.468), P 0.001) were independent risk factors for CAD. Serum lncRNA-MIAT in CAD patients was significantly increased, which may be a potential marker for diagnosis and prognosis of CAD
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