Abstract
Background: Wildfires produce air pollutants that have been associated with complications during pregnancy. This study examined the association between wildfire exposure before and during pregnancy and the odds of CHD in the offspring. Methods: This retrospective cohort study used the California Linked Birth File and the Forestry and Fire Protection data between 2007 and 2010. Patients living within 15 miles of wildfire during pregnancy were considered exposed. Multivariate logistic regression models were used to estimate the association between wildfire exposure by these various exposure metrics and ASD or VSD types of CHD compared to pregnancies without wildfire exposure. Results: Compared to births without wildfire exposure, those with first, second, and third-trimester exposure were associated with a higher risk of atrial septal defect (ASD) with a first-trimester adjusted odds ratio (aOR) of 1.11 (95% confidence interval (CI): [1.04 – 1.18]), second-trimester aOR of 1.12 (95% CI: [1.07 – 1.18]) and third trimester of aOR 1.08 (95% CI: [1.02 – 1.14]). Wildfire exposure during the critical window of fetal heart development (weeks 3-8) was associated with aOR 1.12 (95% CI: [1.02 – 1.23]). Conclusions: Wildfire exposure during pregnancy appears to increase the risk of developing atrial septal defect.
Published Version
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