Abstract
Background: Acute viral hepatitis is associated with significant hepatic dysfunction including lipid metabolism. Variations in the serum lipid fractions in acute viral hepatitis due to hepatic injury may serve as prognostic marker for severity of hepatic injury. Methods: Hospital-based prospective study on acute viral hepatitis. Fifty cases of acute viral hepatitis and 50 age and sex matched controls, (>18 years) were studied. Routine biochemical investigation, hepatotropic viral serology and fasting serum lipid fractions were analysed for changes in patients with acute viral hepatitis. Chi-square test was used for comparing variables. A ‘p value’ 0.05). Jaundice (100%) and high coloured urine (100%) were the commonest presentations. Hepatitis A virus (52%) and Hepatitis E virus (30%) were commonest aetiological agents. Serum cholesterol, triglycerides, low density lipoprotein (LDL) were significantly higher (p 0.05). Complications were seen in 7 (14%) cases with hepatic encephalopathy being the commonest (6%). Serum cholesterol, triglycerides, LDL were significantly higher and HDL was significantly lower in hepatitis with complications compared to uncomplicated hepatitis (p<0.01). Conclusion: Acute viral hepatitis leads to significant alterations of serum lipid fractions which may serve as an indicator of severity of liver damage and be helpful in assessing the prognosis of patients with acute viral hepatitis.
Highlights
Acute viral hepatitis (AVH) continues to be a major public health burden in developing countries like India [1]
The present study was a hospital-based prospective study, carried out between July 2012 and June 2013, in patients with acute viral hepatitis admitted to general medical ward (MW) of Gauhati Medical College & Hospital, Guwahati, a tertiary care hospital in northeast India catering to several north eastern states of the country
Hepatitis A virus (52%) was the commonest aetiological agent followed by Hepatitis E virus (30%), (Table 4)
Summary
Acute viral hepatitis (AVH) continues to be a major public health burden in developing countries like India [1]. Previous studies have documented the alterations of serum lipids in patients suffering from acute hepatitis due to hepatotropic virus [8]. Triglycerides, low density lipoprotein (LDL) were significantly higher (p
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