Abstract
Purpose. Study of the etiological structure of lethality from acute viral hepatitis and its comparison with morbidity and mortality for the period of 2009−2018.Materials and methods. State Reporting Forms No. 1 “Report on Infectious, Parasitic and Non-Infectious Diseases” for the period of 2009−2018 were studied. The data was processed by the Microsoft Office Excel statistical package.Results. In Kyrgyzstan, during the period of 2009−2018, 138,612 cases of acute viral hepatitis (AVH) were detected, of which 109 patients had fatal outcomes. In the general structure of the latter, the proportions of patients with acute hepatitis B (AHB 36.7%) and A (AHA, 35.7%) were approximately the same. In every fifth case, “unverified acute viral hepatitis (UAVH)” was diagnosed (22.9%). Acute hepatitis C (AHC) was the cause of death in 4 patients (3%), and hepatitis D virus (HDV) infection in 1 patient. Among the deceased, there were no cases of hepatitis E. Lethality from AHB was recorded in 5 children, and from hepatitis C in one child. At the same time, 9 out of 25 patients with “Unverified Acute Viral Hepatitis” were children. Over the period of 2009−2018, the incidence of AHB was 31.3 times lower than that of all AVH in general (240.9 and 7.7⁰/0000, AVH and AHB, respectively), the mortality rate was 2.7 times lower (0.19 and 0.07⁰/0000, AVH and AHB, respectively), and the lethality rate was 11.4 times higher (7.9 and 89.8⁰/0000, AVH and AHB, respectively). The average incidence of AHB in children was 6.4 times lower (7.7 and 1.2⁰/0000, total and children, respectively), the mortality rate was 2.3 times lower (0.07 and 0.03⁰/0000, total and children, respectively), and the lethality rate was 1.8 times higher (89.8 and 165.9⁰/0000, total and children, respectively).Conclusion. The existence of morbidity and lethality in adults and children from acute hepatitis indicates a high disease burden for the country. The high proportion of AHB and AHA in the structure of AVH mortality requires improving the quality of immunization of children and expanding the coverage of adults with vaccination against these viral hepatitis. The increase in lethality against the background of a tenfold decrease in the incidence of AVH points out that the number of patients who have died from this pathology does not decrease.
Highlights
The morbidity caused by hepatitis B virus (HBV) causes great damage to the socio-economic condition of the country, regardless of the level of deve lopment [1,2,3]
Acute hepatitis C (AHC) was the cause of death in 4 patients (3%), and hepatitis D virus (HDV) infection in 1 patient
The consequence of this is the presence of the incidence of acute viral hepatitis B (AHB) in the population [4,5,6,7]
Summary
The morbidity caused by hepatitis B virus (HBV) causes great damage to the socio-economic condition of the country, regardless of the level of deve lopment [1,2,3]. World experience shows that despite the successful implementation of vaccination programs against HBV infection, a certain part of children and adults remain unreached by this preventive measure. The consequence of this is the presence of the incidence of acute viral hepatitis B (AHB) in the population [4,5,6,7]. This situation is typical for the Kyrgyz Republic, where the average cumulative incidence of AHB in the population within the period of 2009−2018 was 8 cases per 100,000 population, including people over 15 years old — 10.70/0000, and children — 1.30/0000 [8]. In our country, the epidemiological surveillance system continues to detect lethal cases of AVH, which occur even among pregnant women [15–17]
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