Link Between PTSD and Autoimmune Diseases: A Path to Effective Treatment. Literature review

Abstract

Introduction and Objective: PTSD is a psychiatric disorder associated with the experience of a traumatic event in the past. Changes in the immune system are presented as one of the mechanisms involved in its pathophysiology. The purpose of this review is to investigate the potential link between PTSD and autoimmune diseases, as well as to highlight the therapeutic implications. Review methods: The review is based on scientific publications in PubMed, Science Direct and NCBI databases. After an initial evaluation of the articles, primarily observational studies and meta-analyses on the relationship between PTSD and autoimmune diseases, the underlying pathophysiology, and new potential therapeutic options were selected. Abbreviated description of the state of knowledge: PTSD is associated with numerous changes in the immune and neuroendocrine systems. As a result, patients affected by the disorder are susceptible to developing somatic diseases, including autoimmune diseases. Numerous studies indicate a reciprocal effect on the increased risk and aggravation of symptoms for PTSD and autoimmune diseases due to certain similarities in pathophysiology. New treatment options for PTSD targeting the immune system with anti-inflammatory and immunomodulatory drugs are currently being explored. Summary: This review article highlights the existing reciprocal relationship between PTSD and autoimmune diseases, which carries important clinical implications. The authors of the review emphasize the importance of better understanding the pathophysiology of PTSD and the early diagnosis and treatment of people with PTSD, as well as the need to develop new effective treatments for PTSD that can help reduce the risk of developing autoimmune diseases in people with the disorder. As suggested, treatment targeting the immune system may be an effective therapeutic option for patients with PTSD.