Linfomas primarios de mama. Presentación de nuestra casuística y revisión de la literatura científica

Abstract

Less than 1% of all malignant breast tumors are due to primary lymphoma.Because the frequency of this type of tumor is low, primary lymphoma is often overlooked in the preoperative evaluation of patients with breast tumors. Furthermore, there are no specific radiological or clinical findings that would suggest this entity.Diagnosis is based on histopathology. Before a diagnosis of primary breast lymphoma can be made, extensive investigations must be performed to ascertain that the criteria defined by Wisemand and Liao are fulfilled.The treatment strategy is surgical for diagnostic purposes but the extent of the surgery does not influence local control of the disease. The treatment of choice is radiation therapy with or without chemotherapy, depending on the tumoral phenotype.The only statistically significant prognostic factor in this entity is the Ann-Arbor staging system. Using the 12 de Octubre Hospital’s database as reference, we describe three cases of primary breast lymphoma diagnosed between 1990 and 2005. A comprehensive review of the literature is also provided.