Abstract
Quantitation of spindle-shaped fibroblastoid CFC in human bone marrow by limiting dilution analysis argues in favor of one type of progenitor. We suggest the existence of 2 functional kinds of spindle-shaped fibroblastoid cells in regard with their ability to generate fat-storing cells or express α-smooth muscle actin. Mechanisms of terminal differentiation Involved are not well understood. We failed to observe any spindle-shaped fibroblastoid CFC in peripheral blood cythapheresis collected for APBSC, wich suggest that hematopoietic recovery is supported by stromal cells maintained in situ after conditioning and no mobilisation of spindle-shaped fibroblastoid cell progenitors after chemotherapy.
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