Abstract
Limb Regeneration in Axolotl: Is It Superhealing?
Highlights
Regenerative medicine is an emerging field of medical research that promises to unlock the secrets of how the body can regenerate itself
One of the main approaches to mammalian regenerative medicine is the isolation of stem cells, followed by manipulations that are aimed at directing their differentiation towards the morphogenesis of complex structures[1]
Fgf-8, on the other hand, does display a pattern of expression during regeneration that correlates more, not perfectly, with the model of regeneration by intercalation. It is up-regulated at medium and late bud stages, which represent the beginning of the redevelopment phase, and is down-regulated at palette when the morphogenesis of the fingers becomes apparent, which is similar to the expression pattern observed during axolotl limb development[33]
Summary
Regenerative medicine is an emerging field of medical research that promises to unlock the secrets of how the body can regenerate itself. Fgf-8, on the other hand, does display a pattern of expression during regeneration that correlates more, not perfectly, with the model of regeneration by intercalation It is up-regulated at medium and late bud stages, which represent the beginning of the redevelopment phase, and is down-regulated at palette when the morphogenesis of the fingers becomes apparent, which is similar to the expression pattern observed during axolotl limb development[33]. These interactions are essential for the development of multiple structures (e.g., teeth, limbs, kidneys, lungs) in vertebrates[38,39,40,41,42,43,44] It seems that in the regenerating limb, nerves are important mediators of these epithelial/mesenchymal interactions that occur between the blastema cells and the AEC[5,18]. Additional studies will be necessary to better understand the requirement of nerves and the epithelial/mesenchymal interactions and to identify the genes responsible for mediating these interactions in the context of regeneration
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