Abstract
Zebrafish Fins as a Model System for Skeletal Human Studies
Highlights
One of the main goals of evo-devo synthesis is the search for genetic and molecular embryological synapomorphies to support systematics at a molecular level
While in the regenerating fin, histological analysis[53] has shown that a number of blastemal cells that adjoin the basal epidermis differentiate into scleroblasts that synthesize the lepidotrichia[35,53], suggesting the participation of epidermal-blastema interactions for bone regeneration, cartilaginous condensation occurs away from the epidermis during tetrapod limb regeneration[47]
Despite this recognized peculiarity of the lepidotrichia, the above-mentioned results suggest a close similarity between the effects of inducing signals on the main skeletal tissues in vertebrates and on ray dermal bone formation
Summary
Recent studies on the morphogenesis of the fins of Danio rerio (zebrafish) during development and regeneration suggest that a number of inductive signals involved in the process are similar to some of those that affect bone and cartilage differentiation in mammals and humans. We review the state of the art of this topic by a comparative analysis of skeletal tissue development, regeneration and renewal processes in tetrapods, and fin regeneration in fishes. A general conclusion of this study states that lepidotrichia is a special skeletal tissue different to cartilage, bone, enamel, or dentine in fishes, according to its extracellular matrix (ECM) composition. A number of new inductive molecules are arising from fin development and regeneration studies that might establish an empirical basis for further molecular approaches to mammal skeletal tissues differentiation.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
