Levels of TNF-α and IL-8 in patients with acute and chronic pancreatitis

D.I Grebeniuk,K.Ie Ishcheikin,N.A Liakhovchenko,O.M Zatserkovna

doi:10.31393/reports-vnmedical-2018-22(4)-16

D.I Grebeniuk, K.Ie Ishcheikin + Show 2 more

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https://doi.org/10.31393/reports-vnmedical-2018-22(4)-16

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Abstract

The aim of the study was to research levels of TNF-α and IL-8 in patients with acute and chronic pancreatitis. The study included 86 patients with a confirmed diagnosis of acute edematous pancreatitis (group 1) and 36 patients with a confirmed diagnosis of chronic pancreatitis (group 2). Control group consisted of 70 conditionally healthy people, in whom laboratory and instrumental indices were determined similar to those in patients with acute and chronic pancreatitis. According to the aim and objectives of the study, we analyzed the levels of amylase, lipase, TNF-α and IL-8. The data was processed using the SPSS 20.0 statistical software package for Windows. Determined that the level of amylase in group 1 was significantly (p<0.01) different from the same indicator in group 2 and in the control group. A similar trend was observed in the study of lipase levels in all groups. At the same time, there was no significant difference between the indicators of group 2 and the control group (p>0.05). Regarding the levels of TNF-α, its highest rates were observed in group 1. In a statistical analysis, it turned out that the level of TNF-α was significantly higher (p<0.05) in group 1 than in group 2 and the control group. The levels of IL-8 both in group 1 and group 2 were significantly higher (p<0.01) than in the control group. At the same time, the value of this indicator also differed significantly in the statistical comparison of groups 1 and 2. Thus, in acute pancreatitis, the levels of TNF-α were significantly higher (p<0.05) than in chronic pancreatitis, but its concentration did not correlate with other studied parameters. IL-8 levels progressively increase with an increase in the degree of activity of the inflammatory process, both in acute and in chronic pancreatitis, and correlates with an increase in such indicators as amylase and lipase in the acute form of the disease.

Highlights

One of the most pressing problems of surgery for a long time remains the problem of pancreatitis
IL-8 levels progressively increase with an increase in the degree of activity of the inflammatory process, both in acute and in chronic pancreatitis, and correlates with an increase in such indicators as amylase and lipase in the acute form of the disease
The aim of the research was to study the levels of TNFα and IL-8 in patients with acute and chronic pancreatitis

Summary

Introduction

One of the most pressing problems of surgery for a long time remains the problem of pancreatitis. The incidence of acute pancreatitis is increasing worldwide, and at present, this disease is one of the most common causes of hospitalization of patients with pathology of the gastrointestinal tract [3, 4]. The incidence and prevalence of chronic pancreatitis is lower than acute, it significantly affects the quality of life of patients characterized by chronic abdominal pain, frequent exacerbations of the disease, and exocrine and/or endocrine insufficiency [5, 6]. The annual incidence of acute pancreatitis varies from 13 to 45 per 100000 people, and chronic - from 5 to 12 per 100000 people. The prevalence of chronic pancreatitis is about 50 per 100000 people [1]

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