Abstract
The aim of the study was to study the activity of TNF-α in patients with acute and chronic pancreatitis. The study included 86 patients with a confirmed diagnosis of acute edematous pancreatitis (group 1) and 36 patients with a confirmed diagnosis of chronic pancreatitis (group 2). A separate control group consisted of 70 conditionally healthy people, in whom laboratory and instrumental indices were determined similar to those in patients with acute and chronic pancreatitis. According to the aim and objectives of the study, we analyzed the levels of amylase, lipase and TNF-α. The level of amylase in group 1 was 1664.1±185.2 U/L and was significantly (p<0.01) different from the same indicator in group 2 (81.2±40.2 U/L) and in the control group (75.2±23.2 U/L). A similar trend was observed in the study of lipase levels in all groups. Thus, the level of lipase in group 1 was 1058.5±120.7 U/L and was significantly (p<0.01) different from the same indicator in group 2 (37.6±22.1 U/L) and in the control group (42.7±13.8 U/L). At the same time, there was no significant difference between the indicators of group 2 and the control group (p>0.05). Regarding the levels of TNF- α, its highest rates were observed in group 1 - 65.2±7.8 pg/mL. In group 2, the level of this marker was 52.5±6.2 pg/mL, and in the control group - 48.9±5.6 pg/mL. In a statistical analysis, it turned out that the level of TNF-α was significantly higher (p<0.05) in group 1 than in group 2 and the control group. Although we noted an increase in the numerical index of the level of TNF-α in group 2, however, there was no significant difference between this indicator in group 2 and the control group (p>0.05). So, in acute pancreatitis, the levels of TNF-α were significantly higher (p<0.05) than in chronic pancreatitis, but its concentration did not correlate with other studied parameters.
Highlights
One of the most actual problems of abdominal surgery for a long time remains the question of pancreatitis
Chronic pancreatitis is lower in incidence and prevalence than acute pancreatitis, it significantly affects patients' quality of life; it is characterized by chronic abdominal pain, frequent disease exacerbations, and exocrine and/or endocrine insufficiency [5, 6]
We noted an increase in the numerical index of the level of TNF-α in group 2, there was no significant difference between this indicator in group 2 and the control group (p>0.05)
Summary
One of the most actual problems of abdominal surgery for a long time remains the question of pancreatitis. Despite the continuous improvement of ideas about the nature and mechanisms of development of pancreatitis, the improvement of diagnostic and therapeutic measures, the problem of acute and chronic pancreatitis remains extremely relevant [1, 2]. Chronic pancreatitis is lower in incidence and prevalence than acute pancreatitis, it significantly affects patients' quality of life; it is characterized by chronic abdominal pain, frequent disease exacerbations, and exocrine and/or endocrine insufficiency [5, 6]. The annual incidence of acute pancreatitis ranges from 13 to 45/100,000 persons, and chronic pancreatitis from 5 to 12/100,000; the prevalence of chronic pancreatitis is about 50/100,000 persons [1]. The study of the activity of the inflammatory marker TNF-α in patients with acute and chronic pancreatitis is of scientific interest
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