Level change of plasma IL-8 before and after interventional therapy on patients with ventricular septal defect

Abstract

Objective To observe the changes of plasma interleukin-8 (IL-8) and cardiac performance on children with ventricular septal defect (VSD) after interventional therapy in order to investigate the relationship between the cardiac performance and IL-8.Methods A total of 100 children with VSD for cardiac catheter occlusion in the 1 st Hospital of Hebei Medical University from Feb.2011 to Feb.2013 were enrolled in this study as the VSD group.The control group included 50 healthy children.Concentrations of plasma IL-8 were measured before and the 7th day and 6th month after cardiac catheterization.Before and the 7th day and 6th month after cardiac catheterization,the parameters of left ventricular end diastolic diameter (LVEDD),left ventricular end systolic diameter (LVESD),left ventricular end systolic volume (LVESV),left ventricular end diastolic volume (LVEDV) and left ventricular ejection fraction (LVEF) were measured by echocardiography.The relationships between plasma IL-8 levels and echocardiographic cardiac functional indexes were analyzed.Results (1) The plasma levels of IL-8 in VSD and control group were (0.64 ± 0.08) pg/L and (0.53 ±0.07) pg/L,and there was significant difference between two groups(t =6.61,P ＜ 0.05).IL-8 levels of VSD children at before operation,the 7th day and 6 month after operation were (0.64 ± 0.08) pg/L,(0.69 ± 0.06) pg/L,(0.55 ± 0.05) pg/L respectively,and the differences were statistically significant (t =5.45,t =12.08,P ＜0.05).There was no significant difference in terms of IL-8 at the 6 month after operation and before operation.(2) LVEDD,LVESD,LVEDV,LVESV in VSD children at the 7th days after operation were (41.47 ±3.38) mm,(27.17 ±3.76) mm,(76.72 ± 17.03) ml,(26.23 ±6.13) ml respectively,and (36.21 ± 3.75) mm,(22.49 ± 3.04) mm,(65.38 ± 16.22) ml,(22.23 ± 5.71) ml at the 6 months after operation,significant decreased than that before operation((45.28 ± 3.69) mm,(29.02 ± 3.17) mm,(86.33 ± 19.68)ml,(30.12 ± 7.06) ml; P ＜ 0.05).And the significant difference was seen in the 6th month after operation when compared with that at 7th day after operation(P ＜ 0.05).(3)There were significant positive correlation between level of plasma IL-8 and LVEDD,LVESV,LVESV,LVEDV (r =0.76,0.59,0.66,0.75 respectively; P ＜ 0.05) in VSD group.Conclusion The plasma IL-8 level increased significantly in VSD patients before transcatheter closure,and it reduces after operation which relate with the improvement of cardiac cavity size,suggesting myocardial vascular inflammatory mediators excessive activation of IL-8 participates in and affects the changes of cardiac function in children with VSD. Key words: Ventricular septal defect; Interleukin-8 ; Heart function; Interventional therapy