Relation between epicardial adipose tissue thickness and left ventricularremodeling in dilated cardiomyopathy patients

Abstract

Objective To study the relation of epicardial adipose tissue (EAT) thickness with 1eftventricular remodeling and dysfunction in dilated cardiomyopathy (DCM) patients. Methods One hundred and twenty DCM patients who received treatment from Febuary 2012 to February 2016 were served as DCM group, and 76 healthy subjects undergoing physical examination were served as control group. Their left ventricular end-diastolic diameter (LVEDD), left ventricular end systolic diameter(LVESD), left ventricular end diastolic volume (LVESV), left ventricular end systolic volume (LVEDV), left ventricular end diastolic volume index (LVEDVI), left ventricular end systolic volume index(LVESVI), sphericity index (SI), leftventricular ejection fraction (LVEF), and EAT thickness were measured by routine cardiac ultrasonography and compared between two groups. Results The levels of LVESD, LVEDD, LVESV, LVEDV, LVESVI, LVEDVI and EAT thickness in DCM group were significantly higher, and the levels of LVEF, SIS and SID in DCM group were significantly lower (P 0.05) Linear correlation analysisshowed that the EAT thickness was positively related with the LVESD, LVEDD, LVESV, LVEDV, LVEDVI, LVESVI, SISand SID (r= 0.247, 0.231, 0.256, 0.267, 0.293, 0.281, 0.261, 0.237, P 0.05). Logistic multifactor regression analysis showed that EAT thickness was an independent risk factor for left ventricular remodeling in DCM patients (OR= 0.793, 95%CI: 0.431-1.734, P= 0.039). Conclusions The EAT thickness is significantly related with the left ventricular remodeling and can be used as an independent risk factor for predicting left ventricular remodeling in DCM patients. Key words: Cardiomyopathy, dilated; Adipose tissue; Ventricular remodeling; Ventricular dysfunction, left