Abstract
After combined treatment of rats with 0.8 mmol NaNO2/kg intraperitoneally and 2.4 mmol CO/kg subcutaneously the leucine aminopeptidase activity in plasma increased significantly. Doses of 0.8 mmol NaNO2/kg or 2.4mmol CO/kg alone did not change the enzyme activity. Single injection of 9.6 mmol CO/kg also produced an increase of the leucine aminopeptidase activity in the plasma of both normal and adrenalectomized rats. The results support the assumption that the enhancement of leucine aminopeptidase activity after carbon monoxide poisoning is an oxygen deficiency effect, and not an effect which is mediated by the adrenals.
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