Letter to the editor RE: Reuling etal., 2018 'liver injury in uncomplicated malaria is an overlooked phenomenon: An observational study'.

Arjen M Dondorp,Nicholas J White,Nicholas P Day,Rob W Van Der Pluijm

doi:10.1016/j.ebiom.2021.103377

Arjen M Dondorp, Nicholas J White + Show 2 more

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https://doi.org/10.1016/j.ebiom.2021.103377

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Abstract

Reuling et al. report that liver enzyme abnormalities (transient increases in aspartate transaminase (AST) and alanine transaminase (ALT)) [1] are common in experimental P. falciparum Controlled Human Malaria Infections (CHMI) in healthy volunteers and uncomplicated falciparum malaria in returning travellers.

Highlights

Reuling et al report that liver enzyme abnormalities (transient increases in aspartate transaminase (AST) and alanine transaminase (ALT)) [1] are common in experimental P. falciparum Controlled Human Malaria Infections (CHMI) in healthy volunteers and uncomplicated falciparum malaria in returning travellers
We confined our analysis to patients treated with conventional artemisinin combination therapies (ACTs) (Table 1)
Dondorp et al / EBioMedicine 68 (2021) 103377 malaria, the incidence of a > 5-fold increases in ALT or AST after antimalarial treatment was below 2¢0% [3]

Summary

Introduction

Reuling et al report that liver enzyme abnormalities (transient increases in aspartate transaminase (AST) and alanine transaminase (ALT)) [1] are common in experimental P. falciparum Controlled Human Malaria Infections (CHMI) in healthy volunteers and uncomplicated falciparum malaria in returning travellers. Article History: Received 5 March 2021 Accepted 19 April 2021 Available online 25 May 2021 This prompted us to review prospectively collected data on these biochemical markers of liver injury from a recently published antimalarial treatment trial in patients with uncomplicated falciparum malaria in Southeast Asia [2].

Results

Conclusion