Abstract
Dondorp et al. highlight that the incidence of liver function test (LFT) abnormalities (> 5·0x the upper limit of normal (ULN)) in SE-Asian malaria patients after artemisinin combination therapies (ACTs) is roughly three times lower than observed in Controlled Human Malaria Infection (CHMI) studies in malaria naïve-Dutch volunteers and uncomplicated falciparum malaria in returning travelers [1,2]. This remarkable difference indeed requires further consideration.
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