Abstract
Objective: Left ventricular diastolic dysfunction is a common cardiac condition in obese individuals. An updated review and meta-analysis focusing on this issue is lacking, we analyzed the literatures in order to conduct comprehensive information on the left ventricular diastolic function changes, as assessed by echocardiography, associated to obesity. Methods: A literature search using the keywords 'left ventricular diastolic dysfunction', 'diastolic dysfunction', 'obesity', 'obese' 'body mass index' and 'echocardiography' was performed in order to identify relevant papers. Full articles published in English in peer-reviewed journals in past 20 years reporting studies in adult obese individuals were considered. Results: A total of 11 studies including 5171 participants (2764 adults are obese patients) were considered. Obesity was defined as a BMI of ≥30kg/m2.Meta-analysis of selected 11 studies (2764 obesity subjects and 2407 normal weight) found that there is no difference of peak late diastolic mitral flow velocity (A) and deceleration time of early diastolic flow wave (DT) between the two groups, while other related parameters such as peak late diastolic mitral flow velocity (A) and E/A ratio, isovolumic relaxation time (IVRT), early diastolic myocardial velocities (E') and E/E' ratio are significant different between obese individuals and non-obese controls, the values of A, IVRT and E/E' were higher in obesity group compared with that of in control group, while the values of E/A ratio and E' were lower in obesity group. Conclusions: Our study shows that left ventricular diastolic dysfunction is present in obese population, Body mass index was found as a significant predictor for DD.
Highlights
Obesity is a major public health epidemic and it has been increasing at alarming rates worldwide in all age groups [1]
Left ventricular diastolic dysfunction (DD) is a common cardiac condition and contributes significantly to the future development of heart failure with preserved systolic function in obese patients [3,4].Several studies have evaluated the relation between body mass index (BMI) and left ventricular DD, BMI was found as a significant predictor for DD even after adjusting for age, mean arterial pressure and left ventricle mass index [5,6]
Obesity is associated with diabetes mellitus, hypertension and increased cardiovascular morbidity and mortality [22], especially it is an independent predictor of future development of heart failure [23]
Summary
Obesity is a major public health epidemic and it has been increasing at alarming rates worldwide in all age groups [1]. Substantial epidemiologic data indicated that obesity is associated with significant alteration in left ventricular structure and function and it is an independent predictor of most cardiovascular morbidity and mortality, as well as overall mortality in populations [2]. Left ventricular diastolic dysfunction (DD) is a common cardiac condition and contributes significantly to the future development of heart failure with preserved systolic function in obese patients [3,4].Several studies have evaluated the relation between body mass index (BMI) and left ventricular DD, BMI was found as a significant predictor for DD even after adjusting for age, mean arterial pressure and left ventricle mass index [5,6]. The associations of these indices with obesity reported in previous studies have been variable [7]. We analyzed the studies published in the past 20 years focusing on this issue in order to provide a review and meta-analysis on the prevalence of left ventricular DD in obese individuals
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
