Abstract
There are several lipoprotein abnormalities in human liver disease, many of which can be related to a reduced LC AT activity. Exchange is known to occur between the lipids of the plasma lipoproteins and their counterparts in the membranes of erythrocytes and other cells. There have been few studies on the effect of this exchange on cell lipid composition and function in liver disease. In agreement with other workers we found erythrocyte lipid composition to be altered in both parenchymal liver disease and obstructive jaundice with increases in cholesterol and lecithin concentrations and raised cholesterol: phospholipid molar ratio (C/P). Plasma LCAT activity showed significant inverse correlations with these erythrocyte lipid changes in parenchymal liver disease but not in obstructive jaundice. Increase in membrane C/P ratio is associated with decreased membrane fluidity, and in erythrocytes from patients we have demonstrated the C/P ratio to be related to an abnormal permeability to sodium and to an enha...
Published Version
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