Leaf Pulp of Carpobrotus deliciousus Attenuate Sodium Arsenate Induced Toxicity

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Carpobrotus deliciousus (CD) is reported to have numerous health benefits. This study determined the influence of the oral and repeated administration of leaf pulp of C. deliciousus (LPCD) on sodium arsenate (SA) (Na3AsO4) induced toxicity in Wistar rats. Thirty male Wistar rats were distributed into five groups of six rats each. Group 1 was given 5 mg/kg body weight (b.w) of SA for 7 days; group 2 was administered 0.5 mL of LPCD for 14 days. Group 3 received 5 mg/kg b.w of SA for 7 days followed by 0.5 mL LPCD for another 7 days, while group 4 was treated with 0.5 mL LPCD for 7 days followed by 5 mg/kg b.w of SA for another 7 days. Group 5 served as the control and received deionized water. After the last treatment, the blood, kidneys, and liver were collected for biochemical analysis. The alkaline phosphatase (ALP), AST, and GPT levels were all significantly (p < 0.05) depleted in groups 1 and 2, while there was no significant (p < 0.05) change in groups 3 and 4 when compared to the control. The HDL, LDL, cholesterol, and triglyceride levels were not significantly (p < 0.05) altered for groups 3 and 4. These findings suggest that oral and repeated exposure to LPCD may ameliorate managing SA-induced toxicity.