Abstract

The study was carried out on 21 white Wistar adult female rats (exposed to 50, 100 and 150 ppb Pb) mated with white Wistar males (ratio 2 female/1 male) exposed to same aluminium levels to obtain F1 generation. There were evaluated in F1 (exposed in utero)number and sex of pups, sex ratio, markers of physical development in the context of data on sexual maturation (age and body weight at vaginal opening). The study pointed out significant decrease of litter size comparative to control group and indirectly correlated but not significantly to exposure level; modification of sex ratio (increase of female pups number/one male pup) comparative to control group, excepting E1 group, and directly correlated to exposure level; delay of vaginal opening comparative to control group and directly, significantly, correlated to exposure level; decrease of body weight at vaginal opening comparative to control group, indirectly, significantly, correlated to exposure level

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