Abstract

The study was carried out on 21 white Wistar adult female rats (exposed to 200, 400 and 1000 ppb Al) mated with white Wistar males (ratio 2 female/1 mal e) exposed to same aluminium levels to obtain F 1 generation. There were evaluated in F 1 (exposed in utero )number and sex of pups, sex ratio, markers of phys ical development in the context of data on sexual matura tion (age and body weight at vaginal opening). The study pointed out significant decrease of litter size com parative to control group and inversely correlated to exposure level; modification of sex ration, increase of fema le pups number/one male pups comparative to C group, not evidently influenced by exposure level; significant delay of vaginal opening comparative to control gr oup but not correlated to exposure level; decrease of body weig ht at vaginal opening comparative to control group, not correlated to exposure level.

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