Abstract
One homozygous and four heterozygous patients with familial hypercholesterolemia received. LDL-apheresis treatment from 1985 to 1987. In the homozygous patient, LDL-apheresis was carried out every 3 or 4 days with a treated plasma volume of 4 liters. In the other four heterozygous patients it was carried out every one or two weeks with 3-5 by dextran sulfate-cellulose-column. The long-term effects of LDL-apheresis on coronary artery stenosis was studied by coronary angiography. The angiographic measurement of coronary artery stenosis was scored on Coronary Atherosclerosis Index (CAI). Treatment by LDL-apheresis maintained mean plasma cholesterol levels between 130 and 180mg/dl, prevented the progression of coronary stenosis and caused the regression of skin xanthomas. All the patients have noted improvement in their angina pectoris after the LDL-apheresis treatment.
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