Evaluation of correlation between myocardial perfusion abnormality and coronary artery stenosis with SPECT/CT

Abstract

Objective To investigate the correlation between myocardial perfusion abnormality and coronary artery stenosis using MPI and CTCA. Methods A total of 169 patients (102 males, 67 females, age: 7-80 (56.1±12.1) years) who underwent MPI and CTCA were enrolled. MPI and CTCA images were fused, then myocardial perfusion abnormal areas and corresponding coronary arteries were found. According to bull's-eye map, myocardial segments were scored by a 5-grade criteria and summed stress score (SSS), summed rest score (SRS), summed difference score (SDS) were obtained. All subjects were divided into mild, moderate and severe groups according to the SSS. The correlation between abnormal area and coronary artery stenosis was analyzed by Spearman rank correlation analysis. Results The mild, moderate and severe groups had 89, 37 and 43 subjects respectively, and numbers of abnormal areas were 89, 42, and 49 respectively in the 3 groups. Among the supplying coronary arteries of abnormal areas, 20 were normal, 23 with stenosis<25%, 28 with stenosis 25%-50%, 55 with stenosis 51%-74%, 47 with stenosis 75%-99%, 7 totally occluded. The correlations between SSS, SDS of perfusion abnormal area and coronary artery stenosis were significant (rs=0.617, 0.435, both P<0.05). In mild, moderate and severe groups, the correlation coefficients between SSS and coronary artery stenosis were 0.456, 0.652 and 0.417, the correlation coefficients between SDS and coronary artery stenosis were 0.332, 0.491, 0.305. Conclusions The SPECT/CT fusion technology is helpful in diagnosis of functionally relevant coronary artery lesions. In moderate group, the correlation between myocardial perfusion abnormality and coronary artery stenosis is more significant. Key words: Coronary stenosis; Hemoperfusion; Tomography, emission-computed, single-photon; Tomography, X-ray computed; Coronary angiography; Adenosine triphosphate