Abstract
Vulvar ulceration can occur as the primary or secondary event in a wide variety of processes: infections, autoimmune and/or inflammatory diseases and dermatoses, neoplasms and entities of unknown etiology. Diagnosis relies on positive criteria: acute onset of one or several deep, large, necrotizing and extremely painful ulcerations in young women, usually virgins, preceded by fever sometimes associated with tonsillitis. Specific microbiological, histological, immunological, and other investigations are often required to establish a diagnosis. The case of an 18-year-old woman with typical clinical features of acute vulvar ulcer is reported. The main differential diagnoses are discussed.
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