Abstract
Background Recent work in hydrocephalus modelling has drawn attention to the potential role of disruption of a pulsation absorber mechanism in the intracranial compartment. Therefore, characterization of cerebral hemodynamics is essential for understanding complex intracranial dynamics under normal and diseased conditions, diagnosing and treating patients suffering from hydrocephalus, and designing medical devices. To this end, we have developed a procedure for generating physiologically accurate models of the cerebral hemodynamics by coupling clinical data and the multiscale modelling approach.
Highlights
Recent work in hydrocephalus modelling has drawn attention to the potential role of disruption of a pulsation absorber mechanism in the intracranial compartment
Characterization of cerebral hemodynamics is essential for understanding complex intracranial dynamics under normal and diseased conditions, diagnosing and treating patients suffering from hydrocephalus, and designing medical devices
We have developed a procedure for generating physiologically accurate models of the cerebral hemodynamics by coupling clinical data and the multiscale modelling approach
Summary
Recent work in hydrocephalus modelling has drawn attention to the potential role of disruption of a pulsation absorber mechanism in the intracranial compartment. Characterization of cerebral hemodynamics is essential for understanding complex intracranial dynamics under normal and diseased conditions, diagnosing and treating patients suffering from hydrocephalus, and designing medical devices. To this end, we have developed a procedure for generating physiologically accurate models of the cerebral hemodynamics by coupling clinical data and the multiscale modelling approach
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