Abstract
BackgroundLactobacillus gasseri SBT2055 (LG2055) inhibits dietary fat absorption in rats and exerts preventive effects on abdominal adiposity in rats and humans. The present study aimed to evaluate the effects of LG2055 on postprandial serum lipid responses in Japanese subjects with hypertriacylglycerolemia after the intake of oral fat-loading test (OFLT) meals.MethodsWe conducted a single-blind, placebo-controlled, within-subject, repeated-measure intervention trial. Twenty subjects initially ingested the fermented milk (FM) without LG2055 for 4 weeks (control FM period), followed by a 4-week washout period, and then consumed FM containing LG2055 for 4 weeks (active FM period). The subjects were asked to consume FM at 200 g/day. At the end of each 4-week period, an 8-h OFLT was conducted. Blood samples were collected at fasting and every hour for 8 h after OFLT meal intake. Thereafter, postprandial serum non-esterified fatty acid (NEFA) and triacylglycerol (TAG) levels and fasting blood parameters were measured.ResultsThe OFLT showed that the postprandial serum NEFA levels from 120 to 480 min and the postprandial serum TAG level at 120 min in the active FM period were significantly (P < 0.05) lower than those in the control FM period. The fasting serum NEFA level in the active FM period significantly (P < 0.001) decreased at week 4 from the initial period compared with the control FM period.ConclusionsThe consumption of probiotic LG2055 reduced postprandial and fasting serum NEFA levels, suggesting its possible contribution to the reduction of the risk for obesity and type 2 diabetes mellitus.Trial registrationUMIN000011605
Highlights
Lactobacillus gasseri SBT2055 (LG2055) inhibits dietary fat absorption in rats and exerts preventive effects on abdominal adiposity in rats and humans
We examined the effects of the probiotic LG2055 on postprandial serum lipid responses in Japanese subjects with hypertriacylglycerolemia, referring to an oral fat-loading test (OFLT) study of Lopez et al [18]
Active fermented milk (FM) significantly decreased the postprandial serum non-esterified fatty acid (NEFA) levels from 120 to 480 min after the intake of the OFLT meals compared with the control FM, leading to a significantly lower NEFA-incremental area under the curve (iAUC) (P < 0.01)
Summary
Lactobacillus gasseri SBT2055 (LG2055) inhibits dietary fat absorption in rats and exerts preventive effects on abdominal adiposity in rats and humans. Lactobacillus gasseri SBT2055 (LG2055), a probiotic lactic acid bacterium that originates from the human intestine [1,2] and has the ability to improve the intestinal environment [3], was demonstrated to diminish lymphatic triacylglycerol (TAG) transport and increase fecal fatty acids excretion, thereby inhibiting intestinal fat absorption [4], and to have anti-obesity effects in rats [4,5,6], mice [7], and humans [8,9]. Energy intake reduction by suppression of dietary fat absorption is a strategy for the regulation of postprandial lipid metabolism. To our knowledge, no intervention study has been conducted to examine postprandial lipid metabolism using probiotics
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