Abstract
Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.
Highlights
Plant-based therapies for many diseases have been studied for a long time
Other biochemical parameters (ALB, blood urea nitrogen (BUN), CRE, etc.) remained unchanged. These results indicate that 30 min after jojoba oil administration, serum lipid levels increased because of increased non-esterified fatty acid (NEFA)
To confirm that the alterations in gene expression levels in the associated tissues/organs were correlated with elevated serum NEFA levels, we examined the relationship between gene expression levels in various tissues/organs and serum NEFA levels (Table 5)
Summary
Plant-based therapies for many diseases have been studied for a long time. Research is currently being conducted to assess the application of plant-derived components such as extracts and essential oils for medical treatments [1,2] and insecticides [3]. Aromatherapy massages are administered by diluting essential oils with carrier oils. Numerous studies on massage therapy as a complementary or alternative therapy or in the context of sports medicine have been carried out, limited information is available regarding. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Mice were topically administered 4 μL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil.
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