Abstract
Background and Aim:Many metabolic and immunological changes occur during the transition period. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemşin sheep during the peripartum period.Materials and Methods:Serum NAb, BHBA, and NEFA levels were determined from the blood samples collected from Tuj and Hemşin sheep on days 30 and 15 before birth, on the day of birth (day 0), and on days 15 and 30 after birth.Results:NAb titers were found to be higher in Tuj than in Hemşin sheep (p<0.001). No statistically significant difference was found in serum BHBA concentrations of both breeds on all sampling days (p>0.05). The serum NEFA level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemşin sheep (p<0.05), while no difference was found in samples collected at the other time points.Conclusion:This study indicated that serum NAb titers significantly changed in Tuj and Hemşin sheep during the transition period. Serum BHBA and NEFA concentrations increased during the last stages of pregnancy and decreased after birth. Based on these findings, it is suggested that the immunological status could vary by the breed of sheep or various factors that affect the sheep’s metabolic state.
Highlights
In mammals, innate immunity plays an important role in preventing and treating infections [1]
The serum non-esterified fatty acid (NEFA) level was lower in Tuj sheep in the last 15 days of pregnancy compared to Hemşin sheep (p
This study indicated that serum natural antibodies (NAb) titers significantly changed in Tuj and Hemşin sheep during the transition period
Summary
Innate immunity plays an important role in preventing and treating infections [1]. Natural antibodies (NAb) are important in humoral immunity [2]. They are defined as antigen-binding and considered a humoral part of the innate immune system in non-immunized individuals [3]. In cooperation with the complement system, they serve as the first defense mechanism of the immune system [6] They bind directly to pathogens [7,8], contributing to their direct neutralization, and play a role in the defense mechanism by the activation of the complement system [9]. Innate immunity plays an important role against to infections and natural antibodies (NAb) are important in immunity. This study aims to determine a connection between serum NAb titers, beta-hydroxybutyric acid (BHBA), and non-esterified fatty acid (NEFA) concentrations in Tuj and Hemşin sheep during the peripartum period
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