Abstract
Lack of formation of Reissner fiber leads to hydrocephalus
Highlights
The subcommissural organ (SCO) differentiates early in ontogeny and remains fully active during the entire life span
We have investigated several animal models in which the SCO would play a role in the pathogenesis of hydrocephalus
We have performed a comparative analysis of the changes occurring in the SCO-Reissner fiber (RF) complex of these animal models, with the aim to find a landmark common to all hydrocephalic animals that might help to unfold the mechanism of SCO-dependant hydrocephalus
Summary
S Rodríguez, LF Bátiz, AR Ortloff, K Vío, RI Muñoz, LM DeGraff, JP Graves, DJ Stumpo, PJ Blackshear, DC Zeldin, J Goto, T Tezuka3,. Address: 1Instituto de Histología y Patología, Universidad Austral de Chile, Valdivia, Chile, 2National Institute of Environmental Health Sciences (NIEHS, NIH), Research Triangle Park, NC, USA and 3Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Japan. Published: 20 December 2007 Cerebrospinal Fluid Research 2007, 4(Suppl 1):S25 doi:10.1186/1743-8454-4-S1-S25. 51st Annual Meeting of the Society for Research into Hydrocephalus and Spina Bifida Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1743-8454-4-S1-info.pdf
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