Abstract
This study examined the association of estrogen receptor alpha gene (ESR1) polymorphisms with cardiorespiratory and metabolic parameters in young women. In total, 354 healthy women were selected for cardiopulmonary exercise testing and short-term heart rate (HR) variability (HRV) evaluation. The HRV analysis was determined by the temporal indices rMSSD (square root of the mean squared differences of successive R–R intervals (RRi) divided by the number of RRi minus one), SDNN (root mean square of differences from mean RRi, divided by the number of RRi) and power spectrum components by low frequency (LF), high frequency (HF) and LF/HF ratio. Blood samples were obtained for serum lipids, estradiol and DNA extraction. ESR1 rs2234693 and rs9340799 polymorphisms were analyzed by PCR and fragment restriction analysis. HR and oxygen uptake (VO2) values did not differ between the ESR1 polymorphisms with respect to autonomic modulation. We not find a relationship between ESR1 T–A, T–G, C–A and C–G haplotypes and cardiorespiratory and metabolic variables. Multiple linear regression analysis demonstrated that VO2, total cholesterol and triglycerides influence HRV (p < 0.05). The results suggest that ESR1 variants have no effect on cardiorespiratory and metabolic variables, while HRV indices are influenced by aerobic capacity and lipids in healthy women.
Highlights
Estrogens are important steroid hormones that influence multiple organ systems in both men and women, including cardiovascular, reproductive and skeletal muscle systems [1]
There is evidence that autonomic modulation of heart rate (HR) has been related to aerobic capacity [6,7], lipid profile parameters [10,11] and ESR1 polymorphisms [2,18,19,20,21,22] in different sample populations, these associations in healthy young women have not been investigated
The results suggest a relationship exists between resting heart rate variability (HRV) and functional aerobic capacity
Summary
Estrogens are important steroid hormones that influence multiple organ systems in both men and women, including cardiovascular, reproductive and skeletal muscle systems [1]. Estrogen receptor-mediated actions induce an increase in the metabolism of glucose and fat mass [15,16] and the regulation of peripheral vasodilation [2,15,17] Both of these parameters are closely related to aerobic capacity [12]. There is evidence that autonomic modulation of HR has been related to aerobic capacity [6,7], lipid profile parameters [10,11] and ESR1 polymorphisms [2,18,19,20,21,22] in different sample populations, these associations in healthy young women have not been investigated. This study investigated the relationship between the ESR1 rs2234693 and rs9340799 polymorphisms and HRV, aerobic capacity and serum lipid profiles in young women
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