Abstract

Laboratory evaluation of Novalurone as an Insect Growth Regulator (IGR) against the immature DDT resistant Phlebotomus argentipes (Diptera: psychodidae)

Highlights

  • Female Phlebotomus argentipes (Diptera: Psychodidae) are an obligatory blood-feeders [1,2] and as a consequences of their blood-feeding lifestyle, they become pertinent to harbor Leishmania donovani (Kinetoplastida: Trypanosomatidae) and deliver the lethal-most disease Visceral Leishmaniasis (VL) in Indian subcontinent [3,4]

  • Various synthetic insecticides, Insect Growth Regulators (IGRs) being specific in their mode of action over the insect pests as well as safer to the non-target organisms along with environment [17] sought its potentiality for providing maximum control without disturbing ecological harmony

  • BCBS5934V, analytical grade, manufacturing date- 25th August 2016) manufactured by India based company Sigma-AldrichTM, that was selected as an Insect Growth Regulators (IGRs) for its evaluation against the growth and development of noninfective stages of DDT resistant sand flies

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Summary

Introduction

Female Phlebotomus argentipes (Diptera: Psychodidae) are an obligatory blood-feeders [1,2] and as a consequences of their blood-feeding lifestyle, they become pertinent to harbor Leishmania donovani (Kinetoplastida: Trypanosomatidae) and deliver the lethal-most disease Visceral Leishmaniasis (VL) in Indian subcontinent [3,4]. At VL endemic Indian states, Indoor Residual Spray (IRS) with the insecticide of choice i.e., Dichlorodiphenyltrichloroethane (DDT) remained very popular as a vector control tool since 1953 [5,6] as VL vector population were highly susceptible to it. Increased number of vector survival under the insecticidal effect authenticates the insecticide resistance affecting every aspect of vector control at grass-root level. In this regards, various synthetic insecticides, Insect Growth Regulators (IGRs) being specific in their mode of action over the insect pests as well as safer to the non-target organisms along with environment [17] sought its potentiality for providing maximum control without disturbing ecological harmony. IGRs either interrupts the functioning of endocrine mechanism or synthesis of chitin in cuticular structures during

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