Kutane Manifestation eines nodalen, großzellig-anaplastischen, CD30-positiven, ALK-negativen T-Zell-Non-Hodgkin-Lymphoms

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CD30-positive anaplastic large T-cell lymphomas are either primary cutaneous T-cell lymphomas or primary systemic T-cell lymphomas. Primary cutaneous CD30-positive anaplastic large T-cell lymphomas are usually ALK-negative whereas systemic CD30-positive T-cell lymphomas are more often ALK-positive (60 – 80 %). We present a rare case of a 67 year old patient with a systemic CD30-positive ALK-negative T-cell lymphoma and secondary cutaneous manifestation. This form of a CD30-positive anaplastic large T-cell lymphoma has a bad prognosis and must be treated more aggressively than a primary cutaneous form of CD30-positive ALK-negative anaplastic large T-cell lymphoma.