Abstract
Kinetics of immune reconstitution and immune complications after cell and organ transplantation
Highlights
Recent advances in solid organ and allogeneic hematopoietic stem cell transplantations in the field of oncology have been attributed to stringent HLA matching between donors and recipients and impressive ranges of immunosuppressive therapy
In vitro-activated Natural killer (NK) cells and subsequently adoptively transferred into naïve mouse recipients have an enhanced ability to produce IFNG upon re-stimulation. These findings suggest that once activated mature NK cells may acquire stable, heritable properties that influence their behavior during subsequent infections [27]
Kinetics of immune reconstitution and immune complications after solid organ transplantation In solid organ transplantation (SOT), the proinflammatory responses triggered by the gradual decrease of immunosuppressive agents, but the continuation of antimicrobial and antiviral therapies are believed to be behind the development of post-transplant immune reconstitution pathology [65]
Summary
Recent advances in solid organ and allogeneic hematopoietic stem cell transplantations (allo-HSCT) in the field of oncology have been attributed to stringent HLA matching between donors and recipients and impressive ranges of immunosuppressive therapy. In vitro-activated NK cells (with cytokines IL12, IL15, IL18) and subsequently adoptively transferred into naïve mouse recipients have an enhanced ability to produce IFNG upon re-stimulation. Adaptive and innate immune cells synergize their effort to control latent infections in UCB stem cell transplant patients. The expansion of Tregs inhibits proinflammatory responses in immune cells from the adaptive and innate compartments including NK cells and antigen-presenting cells (APCs) [61]. This is why in vitro expanded Tregs might be an attractive approach to achieve normal kinetics of immune reconstitution after transplantation [62,63,64].
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