Abstract
Soxhlet extractor was used in the extraction of oil from milled seeds of Terminalia catappa using petroleum ether (40-60°). The optimal oil yield was 56.71±1.66% with a viscosity of 40.79±1.05 centipoises. Other parameters of the oil were found as follows; specific gravity-0.9248, refractive index-1.4646, acid value-3.35, peroxide value-8.6, saponification value-166.2, and unsaponifiable matter-1.46. The crude oil extract was water-degummed, bleached and deodorized to generate what we called refined oil. Autoxidation of the crude and refined T. catappa oil extract was done at five different temperatures of 0±0.1°, 20±0.1°, 40±0.1°, 60±0.1° and 80±0.1° and also in the presence of pure α-tocopherol at a concentration of 1.0% (w/v) by measuring peroxide value variations over 96 h. In all evaluations, the refined oil exhibited lower tendency towards autoxidation but not at temperatures above 60±0.1°. The use of Arrhenius equation revealed generally very low activation energies of 0.0261 cal/deg×mol and 0.0122cal/deg×mol for crude oil and antioxidant-treated crude oil, respectively and 0.0690 cal/deg×mol and 0.0177 cal/deg×mol for the refined oil. This study indicates T. catappa seed oil to be potential pharmaceutical oil with excellent characteristics.
Highlights
X* mean of six readings, SD is the standard deviation
Soxhlet extractor was used in the extraction of oil from milled seeds of Terminalia catappa using petroleum ether
Autoxidation of the crude and refined T. catappa oil extract was done at five different temperatures of 0±0.1°, 20±0.1°, 40±0.1°, 60±0.1° and 80±0.1° and in the presence of pure α-tocopherol at a concentration of 1.0% (w/v) by measuring peroxide value variations over 96 h
Summary
X* mean of six readings, SD is the standard deviation. Ezitem are tablets containing 10 mg of ezetimibe, n=6. Results showed no statistical differences suggesting that the developed methods were robust and rugged (Table 2). The developed methods are accurate, sensitive and precise and can be applied to the pharmaceutical formulation
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