Abstract
Biochemical enzymatic assays with electron microscopic studies of biopsied human kidney were made in leptospirosis. There was decreased enzymatic activity together with morphological evidence of tubular cell injury. Cytosomes and cytosegresomes were more abundant in some of the altered cells; mitochondrial and brush border injury were present. Damage to capillaries and a mild glomerular alteration were noted. These data are consistent with a circulating toxin which, acting on capillaries and/or directly on the tubular cell, might be responsible for the kidney failure seen in leptospirosis.
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