Abstract
Abstract The Kahne glycosylation is a convenient synthesis of glycosides and disaccharides or oligosaccharides between glycosyl phenyl sulfoxide and an acceptor in the presence of a glycosylation promoter. This reaction is particularly useful for unreactive acceptors, or the most hindered alcohols. The promoters for this reaction are triflic anhydride (Tf 2 O) and trimethylsilyl triflate (TMSOTf) in a stoichiometric amount or triflic acid in a catalytic amount. This reaction has been further extended to glycosyl alkyl sulfoxide and glycosyl disulfide. This reaction has been widely applied for the synthesis of glycosides, disaccharides, and oligosaccharides.
Published Version
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