Abstract
Glycosyl phosphates have emerged as useful glycosyl donors for stereoselective glycosidic bond formation in the synthesis of oligosaccharides. In this account, we describe some of our work in developing and further expanding this methodology, particularly with the use of propane-1,3-diyl phosphate as the anomeric leaving group. We have studied the reactions of several glycosyl propane-1,3-diyl phosphates with or without C-2 participating groups with a range of glycosyl acceptors in the presence of trimethylsilyl triflate in either stoichiometric or catalytic amount, and demonstrated their application in the synthesis of several disaccharides and also the synthesis of some trisaccharides.
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