Abstract
IUBMB LifeVolume 69, Issue 11 p. 823-823 Issue HighlightsFree Access Issue Highlights First published: 27 October 2017 https://doi.org/10.1002/iub.1691AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 824 Emerging roles of Syndecan 2 in epithelial and mesenchymal cancer progression Maria Mytilinaiou, Dragana Nikitovic, Aikaterini Berdiaki, Antonis Kostouras, Antonis Papoutsidakis, Aristidis M. Tsatsakis, George N. Tzanakakis Syndecan 2, a cell surface proteoglycan, boasts a unique structure and multiple cellular roles. Increasing evidence demonstrates the ability of syndecan 2 to control cancer cell fate, in a manner depending on the respective tumor type. Researchers have demonstrated that syndecan 2 is a conduit point for signals originating in extracellular matrix capable, through exquisitely regulated downstream mechanisms, to regulate cancer cell functions. Studies on syndecan 2 pinpoint this proteoglycan as a potential target for cancer treatment 1. 896 Biochemical characterization of Argininosuccinate Lyase from M. tuberculosis: significance of a c-terminal cysteine in catalysis and thermal stability Archita Mishra, Avadhesha Suroli A product-based feed-back inhibition of Argininocuccinate Lyase from Mycobacterium tuberculosis (MtArgH), where fumarate covalently modifies a cysteine residue on the c-terminus of MtArgH. This cysteine is found to be crucial for the activity as well as the stability of the enzyme and its modification (succination) leads to a feed-back inhibition of enzyme activity. This phenomenon provides novel insights to the regulation of arginine biosynthesis in M tuberculosis 2. References 1 Mytilinaiou, M., Nikitovic, D., Berdiaki, A., Kostouras, A., Papoutsidakis, A., Tsatsakis, A. M. and Tzanakakis, G. N. Emerging roles of syndecan 2 in epithelial and mesenchymal cancer progression. IUBMB Life. 2017, 69, 824– 833. 2 Mishra, A., Surolia, A. Biochemical characterization of Argininosuccinate Lyase from M. tuberculosis: significance of a c-terminal cysteine in catalysis and thermal stability. IUBMB Life. 2017, 69, 896– 907. Volume69, Issue11November 2017Pages 823-823 ReferencesRelatedInformation
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