Issue Highlights

Abstract

IUBMB LifeVolume 71, Issue 11 p. 1660-1660 Issue HighlightsFree Access Issue Highlights First published: 12 October 2019 https://doi.org/10.1002/iub.2183AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat 1661 Immunological implications of epidermal growth factor receptor signaling in persistent infections Tanushree Mukherjee, Kithiganahalli Narayanaswamy Balaji Epidermal Growth Factor Receptor (EGFR) is classically known for its implications in the etiology of diverse cancers by regulating cell division, differentiation and death. However, the ability of the oncogenic receptor to interact with several cellular intermediates, modulate signaling events and alter gene expression is also tapped by infectious agents to drive their pathogenesis. There is a wide array of nodes where pathogens intersect with EGFR signaling ranging from host cell adhesion/entry to phagosomal maturation and inflammation. Therefore, the understanding of these mechanisms would offer effective EGFR-directed therapeutic/vaccination strategies against the rising incidence of antibiotic-resistant infections. 1685 Leishmania species-dependent functional duality of toll-like receptor 2 Abdollah Jafarzadeh, Maryam Nemati, Iraj Sharifi, Arathi Nair, Divanshu Shukla, Prashant Chauhan, Hossain Khorramdelazad, Arup Sarkar, Bhaskar Saha TLR2-mediated host-protective or disease-exacerbating immune responses are dependent on the infecting Leishmania species. A) An overview of TLR2/2 or TLR1/2, TLR2/6-mediated elimination or persistence of Leishmania in different immune cells. B) Signaling through TLR2/2 in NK-cells, macrophages, DCs and TH1-cells leads to elimination, whereas signaling through TLR1/2 and TLR2/6 in macrophages, TH1-cells and Treg-cells results in persistence of L. major. Signaling through TLR2/2 in DCs, Treg-cells, TH1-cells and CD8+T-cells leads to L. donovani elimination, whereas through TLR2/2, TLR1/2 and TLR2/6 in L. donovani persistence. In L. mexicana, and L. infantum infections TLR2-mediated host-protective responses and L. amazonensis and L. braziliensis infections disease-exacerbating response are triggered 1751 Activation of GPR30 promotes osteogenic differentiation of MC3T3-E1 cells: An implication in osteoporosis Xiaozong Lin, Li Li, Shuliang Wu, Jun Tian, Weizhuo Zheng Expression of GPR30 is upregulated during osteoblast differentiation and that agonism of GPR30 significantly increases some key markers of mineralization including alkaline phosphatase, osteocalcin, osterix, and type I collagen. GPR30 agonism upregulates expression of Runx2, which is recognized as an essential transcription factor involved in bone formation. Additionally, through a series of adenosine monophosphate-activated protein kinase (AMPK) -inhibition experiments using compound C, we show that the positive effects of GPR30 on mineralization and differentiation of pre-osteoblasts are mediated through the AMPK /anti-acetyl-CoA carboxylase (ACC) pathway. Our findings demonstrate the potential of GPR30 as a novel target for the treatment and prevention of osteoporosis. REFERENCE 1Mukherjee Tanushree, Balaji Kithiganahalli Narayanaswamy. Immunological implications of epidermal growth factor receptor signaling in persistent infections. IUBMB Life. 2019, 71, 1661– 1671. 2Jafarzadeh Abdollah, Nemati Maryam, Sharifi Iraj, Nair Arathi, Shukla Divanshu, Chauhan Prashant, Khorramdelazad Hossain, Sarkar Arup, Saha Bhaskar. Leishmania species-dependent functional duality of tolllike receptor 2. IUBMB Life. 2019, 71, 1685– 1700. 3Lin Xiaozong, Li Li, Wu Shuliang, Tian Jun, Zheng Weizhuo. Activation of GPR30 promotes osteogenic differentiation of MC3T3-E1 cells: An implication in osteoporosis. IUBMB Life. 2019, 71, 1751– 1759. Volume71, Issue11November 2019Pages 1660-1660 ReferencesRelatedInformation