Issue Highlights

Abstract

IUBMB LifeVolume 71, Issue 2 p. 151-151 Issue HighlightsFree Access Issue Highlights First published: 09 January 2019 https://doi.org/10.1002/iub.2007AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinked InRedditWechat 152 Lung Inflammation and Disease: A Perspective on Microbial Homeostasis and Metabolism Roberto Mendez, Sulagna Banerjee, Sanjoy K. Bhattacharya, Santanu Banerjee The lung microbiome is significantly smaller than the gut microbiome, both in terms of diversity and biomass. The lower respiratory tract microbiome is constantly replenished by oral and upper respiratory tract microbiota and yet maintains a unique microbial signature. In this review, we provide a perspective on the role of these bacteria in health and disease. We touch upon the known challenges associated with lung microbiome studies and discuss various environmental factors and diseases where commensals are known to play a major role. Finally, we discuss the influence of bacterial metabolites in homeostasis and disease-induced microbial perturbations. 235 MicroRNA-101 Protects Bladder of BOO from Hypoxia- Induced Fibrosis by Attenuating TGF-β- smad2/3 Signaling Baimei He, Qiong Chen, Dongbo Zhou, Lijing Wang, Zhaoqian Liu Patients with benign prostatic hyperplasia often suffer from frequent micturition, the urgency of urination, the urine pain. Even the obstruction was removed, the symptom often remains. Studies have found it may be associated with the fibrosis of bladder after obstruction. Our study found hypoxia promoted the expression of ECM in bladder smooth muscle cells, and the expression of microRNA-101 was up-regulated in the bladder after obstruction. MicroRNA-101 restrained the smad2/3 signaling pathway through depressing the expression of TGFβR1. MicroRNA-101 is emerging as an anti-fibrotic miRNA in the remodeling of bladder after bladder outlet obstruction. 283 Synergistic Antifungal Activity of Isoquercitrin: Apoptosis and Membrane Permeabilization Related to Reactive Oxygen Species in Candida albicans Suhyun Kim, Eun-Rhan Woo, Dong Gun Lee Isoquercitrin (ISO) at non-antifungal concentration has synergistic effect with amphotericin B (AMB) and fluconazole (FLC). These combinations inhibited the activity of superoxide dismutase and lead to disruption of antioxidant system. The collapse of the antioxidant system highly increased reactive oxygen species (ROS) level. Their abnormal concentrations of ROS caused apoptosis in cells treated with ISO and FLC. In contrast, ROS had different effect on the cells treated with ISO and AMB by inducing membrane permeabilization. REFERENCES 1Mendez, R., Banerjee, S., Bhattacharya, S.K., and Banerjee, S. Lung Inflammation and Disease: A Perspective on Microbial Homeostasis and Metabolism. IUBMB Life. 2019, 71, 152– 165. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar 2Wang, N., Duan, L., Ding, J., Cao, Q., Qian, S., Shen, H., and Qi, J. MicroRNA-101 Protects Bladder of BOO from Hypoxia-Induced Fibrosis by Attenuating TGF-β- smad2/3 Signaling. IUBMB Life. 2019, 71, 235– 243. Wiley Online LibraryGoogle Scholar 3 Kim, S., Woo, E.-R., and Lee, D.G. Synergistic Antifungal Activity of Isoquercitrin: Apoptosis and Membrane Permeabilization Related to Reactive Oxygen Species in Candida albicans. IUBMB Life. 2019, 71, 283– 292. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Volume71, Issue2February 2019Pages 151-151 ReferencesRelatedInformation