Abstract
Multiplets due to upfield deuterium isotope effects on the /sup 13/C chemical shifts can be observed when hydrogen exchange is slow relative to the magnitude of the isotope effect. Deuterium isotope effects have been reported for amine, amide, and amino acid systems. The chemical shift values and the magnitudes of the isotope effect for spermidine, as well as for the other substances are in the range 0.055-0.097 ppm/deuteron for the two bond isotope effect. Values at the lower end of this range are observed with higher substitution on the nitrogen or carbon atoms. The three-bond isotope effect is in the range 0.025-0.051 ppm/deuteron. For amino acids and their derivatives, partial deuteration of the ..cap alpha.. ammonium group gives rise to isotopic multiplets in the carboxyl as well as in the identification of terminal residues of peptides.
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