Abstract
Objective:The objective of this study was to identify the multi-drug resistance (MDR) Klebsiella sp. from mastitis milk samples.Materials and Methods:In the current research, 48 clinical mastitis milk samples were collected from Rangpur division, Bangladesh. Confirmation of bovine mastitis (BM) was done by the California Mastitis Test (CMT). All the CMT positive isolates were subjected for the identification of Klebsiella sp. using through a series of cultural and biochemical tests. MDR Klebsiella sp. isolates were determined using the disk diffusion method, and minimum inhibitory zones were measured by following Clinical and Laboratory Standards Institute. MDR patterns of the isolates were also subjected to study by using housefly (Musca domestica).Results:Among the isolates, 62.5% (n = 30/48) revealed the presence of Klebsiella sp. Eight antimicrobial agents including Amoxicillin, Novobiocin, Erythromycin, Vancomycin, Cephradine, Tetracycline, Bacitracin, Methicillin, and housefly (M. domestica) showed complete resistance to Klebsiella sp. On the other hand, Chloramphenicol, Gentamicin, Ciprofloxacin, Azithromycin, Norfloxacin, Levofloxacin, and Nalidixic acid showed sensitivity.Conclusion:This study helps to treat BM with effective antibiotics and helps in an epidemiological study in Rangpur division as well as helps to create public health awareness.
Highlights
Antimicrobial resistance is an ultimate threat to the animal as well as a human being throughout the world
Materials and Methods: In the current research, 48 clinical mastitis milk samples were collected from Rangpur division, Bangladesh
The present study focused on molecular detection of mastitis-causing Klebsiella sp. from clinical mastitis milk samples in Rangpur division, Bangladesh, and the antibiotic susceptibility patterns of the organism were investigated for the first time in Bangladesh
Summary
Antimicrobial resistance is an ultimate threat to the animal as well as a human being throughout the world. Is an important Gram-negative pathogen which may initiate emerging incidence [1,2]. Is an opportunistic bacterium that can cause primary bacteremia as well as urinary tract infection in human and animal [3,4]. As reported by Grohn et al [8], milk production falls and mortality increased in cows affected with Klebsiella sp. They are able to produce a significant loss in the dairy farm by reducing production; which is considered as more fatal as compared to infection caused by Escherichia coli [9]
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