Abstract
The extracts of two isolates in our library of fungal endophytes, Annulohypoxylon multiforme (TC2-046) from the medicinal plant Juniperus communis and a sterile filamentous isolate (KP1-131DD) from the marine alga Scytosiphon lomentaria, displayed similar antimicrobial bioactivity profiles with notable high activity against Staphylococcus aureus. Bioassay-guided fractionation led to the isolation of poly(3 R,5 R-dihydroxyhexanoic acid) oligomers ranging from the trimer to the 29-mer that exhibited significant and selective inhibition of S. aureus and Mycobacterium tuberculosis H37Ra in vitro.
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