Abstract
Isolation and Characterization of a Myotoxic Fraction from Cerastes Vipera Snake Venom
Highlights
The bite of the viper Cerastes vipera has a serious medical problem
A myotoxin was isolated by Gutierrez et al from the venom of the snake; Bothrops nummifer with M.W of 16,000 which lacked phospholipase A2 (PLA2) activity and induced skeletal muscle damage [44]
The present results suggested that dexamethasone with its anti-inflammatory property may ameliorate the muscle damage resulted from crude venom and CV-PL-F4 myotoxin
Summary
The bite of the viper Cerastes vipera has a serious medical problem. C. vipera venom contains a complex mixture of enzymes [1] including phospholipase A2 [2] and proteases [3,4]. Some clinical effects following snake bite are due to PLA2 and proteases which are among the major components of viper venoms. These enzymes share a common cytotoxic activity and similar structural features with non-toxic mammalian pancreatic enzymes, they promote a wide variety of pathological symptoms in animals, such as cardiotoxicity, myotoxicity, anticoagulant activity and hemolysis [5,6,7]. The purposes of the present study are (a) to isolate a fraction having a myonecrotic effect with PLA2 activity from Cerastes Vipera venom, (b) to evaluate the biological properties of the fraction, and (c) to investigate the antimyotoxic action of dexamethasone, Vit E and C and trypsin for the isolated fraction
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