Abstract
The burden of liver disease in Egypt is exceptionally high due to the highest prevalence of hepatitis C virus (HCV) resulting in rising rates of hepatocellular carcinoma (HCC). The aim of the current study was to determine the isoflavones in soy and to evaluate the protective role of soy against CCl4-induced liver damage in rats. Four experimental groups were treated for 8 weeks and included the control group, soy-supplemented diet (20% w/w) group, the group treated orally with CCl4 (100 mg/kg bw) twice a week, and the group fed soy-supplemented diet and treated with CCl4. Blood and liver tissue samples were collected for biochemical analyses and histological examination. The results indicated that protein content was 45.8% and the total isoflavones recorded 167.3 mg/100 g soy. Treatment with CCl4 resulted in a significant biochemical changes in serum liver tissue accompanied with severe oxidative stress and histological changes. Supplementation with soy succeeded to restore the elevation of liver enzymes activities and improved serum biochemical parameters. Moreover, soy supplementation improved the antioxidant enzymes, decreased lipid peroxidation, and improved the histological picture of the liver tissue. It could be concluded that soy-protein-enriched isoflavones may be a promising agent against liver diseases.
Highlights
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world with an estimated 473,000 new cases annually [1]
The results of the current study revealed that treatment with CCl4 resulted in a significant increase in ALT and AST activities, Alpha fetoprotein (AFP) and cholesterol level accompanied with a significant decrease in albumin, total protein, and triglycerides (Table 1)
Animals fed soy-supplemented diet showed a significant decrease in AFP, cholesterol, and triglycerides ; ALT and AST activities and albumin and total protein were comparable to the control
Summary
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world with an estimated 473,000 new cases annually [1]. There are three common tumors of the liver, hemangiomas, adenomas, and focal nodular hyperplasias. Etiology of these benign tumors are either congenital or due to oral contraceptive intake. Malignant tumors include hepatocellular carcinoma, cholangiocarcinoma, hepatoblastoma, and angiosarcoma. The most common and important primary malignant tumor is hepatocellular carcinoma. This tumor is one of the major malignant diseases in the world today. It occurs most frequently in Asia and sub-Saharan Africa. Metastatic spread of tumors from elsewhere in the body to the liver is frequent [5]
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