Abstract
This research aimed at evaluating the hepatoprotective activity of the ethanol extract of Vernonia ambigua in CCl4 induced liver damage in albino rat. A total of 25 wistar albino rats were randomly divided into control and experimental four groups designated as group A-E. Group A serves as the control and were given only distilled water for ten days. Group B, C, D and E were treated with distilled water, silymarin (100mg/kg), 250mg and 500mg/kg of ethanol extract of V. ambigua for nine days. Group B-E also received 3ml/kg of CCl4 on the 10 th day of treatment. After 24 hours, the blood samples were collected through the jugular vein for biochemical analyses. The result showed that albino rats treated with CCl4 had significant (P<0.05) increase in serum ALT, AST and ALP, total bilirubin, cholesterol and triacylglycerols levels and significant decrease (P<0.05) in the levels of total proteins and albumin. Pretreatment with ethanol leaf extract of V. ambigua significantly (P<0.05) decreased the liver marker enzymes, bilirubin, total cholesterol and triacylglycerols. The effect of ethanol leaf extract of Vernonia ambigua (V. ambigua) on CCl4-treated rats albino rats was observed to be dose-dependent. The present investigation suggests that ethanol leaf extract of V. ambigua has a potent hepatoprotective action against CCl4-induced liver damage in rats.
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