Abstract
The present study was carried out to investigate the thrombolytic and antimitotic potentiality of various extracts of fruits of Ficus glomerata, a traditional medicinal plant, using an in vitro assay method. Three crude extracts such as petroleum ether (FGPE), chloroform (FGCE), and methanol (FGME) were used for the study, with a standard (streptokinase) and negative control (sterile distilled water) to validate the method. The thrombolytic nature of the plant was found significant with methanol extract and chloroform and petroleum ether extracts have recorded mild activity, when compared with the negative control (sterile distilled water). The extracts have shown mild clot lysis, that is, 2.16%, 23.06%, 27.60%, and 47.74% of sterile distilled water, FGPE, FGCE, and FGME, respectively, while the standard (streptokinase) has shown 74.22% clot lysis. FGME inhibited the root growth in number as well as length effectively, followed by FGPE, while FGCE exhibited moderate antimitotic activity and it was supported by mitotic index. Therefore, the obtained results suggest that among all the extracts of plant the methanolic extract has shown highest thrombolytic and antimitotic activity.
Highlights
Ficus glomerata Roxb (Moraceae) is widely used in folk medicine for the treatment of various diseases [1]
Bulbs were considered as viable bulbs and water content was removed using tissue paper and these bulbs were selected for the study. These roots were treated with petroleum ether, chloroform, and methanol extracts whereas the positive control is treated with vincristine sulphate
As a part of discovery of cardioprotective drugs from natural resources, the different extractives of Ficus glomerata were assessed for thrombolytic activity
Summary
Ficus glomerata Roxb (Moraceae) is widely used in folk medicine for the treatment of various diseases [1]. The present study is aimed at screening of different extracts of Ficus glomerata fruit for its clot lysis (thrombolytic activity) and antimitotic activity by using an in vitro assay method. These pharmacological activities have been selected because of their great medicinal relevance. The roots of all plants have distinguished regions, one of them being the region of cell division that lies beyond the root cap and after this it even extends a few mm Cells of this region undergo repeated divisions, and the fate of cell division is higher in this region compared to that of the other tissues; this region is called the meristematic region [16]. It is inferred that the chemicals which affect plant chromosomes will affect animals [17]
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