Abstract
Inflammation, a biological response of body tissues to harmful stimuli, is also known to be involved in a host of diseases, such as obesity, atherosclerosis, rheumatoid arthritis, and even cancer. Isoflavones are a class of flavonoids that exhibit antioxidant, anticancer, antimicrobial, and anti-inflammatory properties. Increasing evidence has highlighted the potential for isoflavones to prevent the chronic diseases in which inflammation plays a key role, though the underlying mechanisms remain unclear. Recently, some studies have raised concerns about isoflavones induced negative effects like carcinogenesis, thymic involution, and immunosuppression. Therefore, this review aims to summarize the anti-inflammatory effects of isoflavones, unravel the underlying mechanisms, and present the potential health risks.
Highlights
Inflammation is a biological response stimulated by pathogens, damaged cells, or irritants.Basically, inflammation is an orchestrated protective process to resolve infection, clear out necrotic cells, and trigger tissue repair [1]
Solid evidence has shown that the development of various diseases including obesity, diabetes, metabolic syndrome, atherosclerosis, rheumatoid arthritis, and cancer are strongly correlated with inflammation [3,4,5,6,7]
Though steroidal or non-steroidal anti-inflammatory drugs are currently used to treat inflammation, these drugs are usually accompanied with unexpected side effects, and they are not considered as a good clinical choice for chronic inflammatory disorders [8]
Summary
Inflammation is a biological response stimulated by pathogens, damaged cells, or irritants. Recent investigations have demonstrated that the polyphenols from plant sources, in particular flavonoids, exhibit anti-inflammatory activity both in vitro and in vivo [14,15,16,17] This provides an explanation for the health benefit of vegetarian diets and Chinese medicine, and identifies potential agents for treating inflammatory disorders, including possible therapy for life-threatening diseases. Flavonoids, which include over 6000 identified family members, are a group of phenolic compounds that are widely distributed in plants and fungus They have been well-known for their antioxidant, antimicrobial, and anti-inflammatory health benefits [2,18,19]. In this work, we reviewed the anti‐inflammatory effects of isoflavones, unraveled the underlying mechanisms, and presented the potential risks This depend documenton provides supporting knowledge of fruit physiological effectshealth of flavonoids their some bioavailability. Isoflavone glucosides are hydrolyzed to aglycones by glucosidases
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