Abstract
Ionic liquids (ILs) are molten salts composed of a large organic cation and an organic/inorganic anion. Due to their ionic character, most ILs present advantageous properties over conventional solvents, such as negligible volatility at atmospheric conditions and high thermal and chemical stabilities. The wide variety of IL anion–cation combinations allows these solvents to be designed to display a strong solvation ability for a myriad of active pharmaceutical ingredients (APIs) and (bio)polymers. Given these properties, ILs have been used as solvents and as formulation components in different areas of drug delivery, as well as novel liquid forms of APIs (API-ILs) applied in different stages of development of novel drug delivery systems. Furthermore, their combination with polymers and biopolymers has enabled the design of drug delivery systems for new therapeutic routes of administration.
Highlights
Delivering active pharmaceutical ingredients (APIs) at a controlled rate or offering targeted delivery are appealing therapeutic options [1]
Drug delivery systems can be defined as formulations or devices that enable the introduction of an API into the human body, while improving their efficacy and safety by controlling the rate, time and place of release [4]
In addition to their use as surfactants discussed above that might improve the API solubilization, ionic liquids (ILs) have been investigated as promising solvents, co-solvents and hydrotropes to increase the aqueous solubility of APIs [35]
Summary
Delivering active pharmaceutical ingredients (APIs) at a controlled rate or offering targeted delivery are appealing therapeutic options [1]. Drug delivery systems can be defined as formulations or devices that enable the introduction of an API into the human body, while improving their efficacy and safety by controlling the rate, time and place of release [4]. In drug formulation and administration, the use of volatile organic solvents is commonly applied to improve the solubility of APIs for drug research or to test in vivo effects on biological targets. Design of novel systems polymers and biopolyhas been attempted by using. Due to the advantageous properties of ILs, they have been extensively investigated as different components in drug delivery systems, summarized, attempting to as different components in drug delivery systems, summarized, attempting to unveil novel and more effective options. 1. Applications of ionic liquids (ILs) in drug delivery systems design andand development.
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