Abstract
Design and synthesis of well-ordered drug delivery systems are very important for medicinal and pharmaceutical and health care. Innovations of materials through nanotechnology and hydrogels have synergistically energized the growth of drug delivery. Uniqueness in material chemistry permits the creation of environmentally approachable, biocompatible, biodegradable and targeted drug delivery system. Large numbers of biopolymers have been examined for the design of drug delivery systems. Structure, size, shape and multi-functionality of drug delivery system can be controlled by the nanotechnology combined with biopolymer. Hydrogels have also been investigated as smart delivery systems capable to release, at the appropriate time and site of action, entrapped drugs in response to specific physiological triggers. This review mainly focuses on drug delivery applications of nanoparticles modified biopolymers and effective drug delivery system of biopolymer network based on hydrogels.
Highlights
Pharmaceutical industries are continuously facing challenges and expectations of novel technologies and opportunities for development of drug designing due to medical and health care material research
Yadollahi et al [50] were synthesized chitosan-zinc oxide nanocomposites (ZnONPs) hydrogels by in situ formation of ZnONPs in the chitosan hydrogel matrix to investigate the potential of drug delivery applications
Biopolymers based nanoparticles and hydrogels are promising tools for various biological applications; they have the capability to be used for drug delivery purpose and they showed significant antiviral, anticancer, antibacterial, antimicrobial and antifungal activity
Summary
Pharmaceutical industries are continuously facing challenges and expectations of novel technologies and opportunities for development of drug designing due to medical and health care material research. Both natural and synthetic, both biodegradable and non-biodegradable, have been investigated as drug delivery systems for health care and tissue engineering applications, including bio-ceramics, great biocompatible and composite polymers and hydrogels. This paper provides a short review on the use of biopolymers, nanoparticles modified biopolymers, and hydrogels grafted biomaterials and their potential as a drug delivery system.
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